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VitaminK, the blood-clotting vitamin, is important for the function of numerous proteins within the body, such as the coagulation factors, osteocalcin and matrix-Gla protein.
VitaminK4 is a chemically synthesized VitaminK which plays an important role in the normal blood coagulation system. VitaminK4 arrests the cells in S phase and induces apoptosis. VitaminK4 can be used for the research of cancer, such as prostate cancer and osteosarcoma .
VitaminK5 (hydrochloride) is a naphthoquinones compound, shows trichomonacidal activity in vitro. VitaminK5(hydrochloride) can be used for the research of anti-infection .
VitaminK1-d7 is the deuterium labeled VitaminK1. VitaminK1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism[1][2].
VitaminK1 2,3-epoxide is an inactive metabolite form of VitaminK1 (HY-N0684), which is reduced to active vitamin by microsomal epoxide reductase in the vitaminK epoxide cycle. VitaminK1 2,3-epoxide is involved in blood clotting .
Menaquinone-7 (VitaminK2-7), belongs to a class of K2-vitamin homologs (orally active), is originally discovered as the anti-hemorrhagic factors. Menaquinone-7 inhibits osteoclast bone resorption in vitro and stimulates bone formation in femoral tissue of aged female rats. Menaquinone-7 has a well-researched potential in the prevention of aging-induced bone degeneration. Menaquinone-7 is also a pharmacological option for activating Gla matrix protein and intervening in the progression of calcific aortic stenosis (CAVS) .
VitaminK5 (Synkamin) is a photosensitizer and a antimicrobial agent. VitaminK5 is a specific PKM2 inhibitor with IC50 values of 28, 191 and 120 μM for PKM2, PKM1 and PKL. VitaminK5 induces apoptosis of colon 26 cells. VitaminK5 can be used for the research of infection and cancer, and it also can be used as a preservative for pharmaceuticals, foods, and beverages .
Menaquinone-7-d7 is the deuterium labeled Menaquinone-7. Menaquinone-7 (VitaminK2-7), belongs to a class of K2-vitamin homologs, is originally discovered as the anti-hemorrhagic factors[1]. Menaquinone-7 (VitaminK2-7) is identified as the most bioactive cofactor for the carboxylation reaction of Gla-proteins [2]. Supplementation with Menaquinone-7 (VitaminK2-7) is a pharmacological option for activating matrix Gla protein and intervening in the progression of calcific aortic valve stenosis (CAVS)[3].
Menaquinone-7 (Standard) is the analytical standard of Menaquinone-7. This product is intended for research and analytical applications. Menaquinone-7 (VitaminK2-7), belongs to a class of K2-vitamin homologs (orally active), is originally discovered as the anti-hemorrhagic factors. Menaquinone-7 inhibits osteoclast bone resorption in vitro and stimulates bone formation in femoral tissue of aged female rats. Menaquinone-7 has a well-researched potential in the prevention of aging-induced bone degeneration. Menaquinone-7 is also a pharmacological option for activating Gla matrix protein and intervening in the progression of calcific aortic stenosis (CAVS) .
VitaminK1-d4 is the deuterium labeled VitaminK1. VitaminK1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism[1].
Menaquinone-7- 13C6 is the 13C-labeled Menaquinone-7. Menaquinone-7 (VitaminK2-7), belongs to a class of K2-vitamin homologs, is originally discovered as the anti-hemorrhagic factors[1]. Menaquinone-7 (VitaminK2-7) is identified as the most bioactive cofactor for the carboxylation reaction of Gla-proteins [2]. Supplementation with Menaquinone-7 (VitaminK2-7) is a pharmacological option for activating matrix Gla protein and intervening in the progression of calcific aortic valve stenosis (CAVS)[3].
Menaquinone-4-d7 (VitaminK2(MK-4)-d7) is the deuterium labeled Menaquinone-4. Menaquinone-4 is a vitaminK, used as a hemostatic agent, and also a adjunctive therapy for the pain of osteoporosis.
Menaquinone-4- 13C6 is the 13C-labeled Menaquinone-4. Menaquinone-4 is a vitaminK, used as a hemostatic agent, and also a adjunctive therapy for the pain of osteoporosis.
Menadione bisulfite (sodium) is used as an agent to induce acute oxidative stress, and to function as a plant-defense activator against several pathogens.
Flocoumafen (WL 108366) is a family of orally active vitaminK antagonist (VKA) molecules. Flocoumafen is a second generation anticoagulant rodenticide (ARs) .
6-Hydroxywarfarin is a metabolite of (+) -warfarin. 6-Hydroxywarfarin is a weaker vitaminK antagonist. 6-Hydroxywarfarin is metabolized by the cytochrome P450 isomer 2C9 (CYP2C9) .
NAPQI is the toxic metabolite of Acetaminophen (HY-66005). NAPQI is also an inhibitor of enzymes in the vitaminK cycle. NAPQI is rapidly detoxified by glutathione (GSH), but in situations of GSH deficiency, excess NAPQI reacts with cysteine residues in proteins, causing cell death and toxicity in the liver .
Lapachol, a natural naphthoquinone, is an orally active, potent DHODH inhibitor. Lapachol has immunosuppressive activity on lymphocytes through its direct ability to block DHODH activity and inhibit pyrimidine synthesis. Lapachol is a vitaminK antagonist with antitumor activity and can inhibit DNA and RNA synthesis in neoplastic cells. Lapachol has anti-Leishmania activity .
Tecarfarin (ATI-5923) is an orally active and non-competitive vitaminK epoxide reductase (VKOR) antagonist, and impairs the activation of the vitaminK-dependent clotting factors II, VII, IX and X . Tecarfarin has the antithrombotic activity .
Tecarfarin sodium (ATI-5923 sodium) is a novel orally active non-competitive vitaminK epoxide reductase (VKOR) antagonist, impairs the activation of the vitaminK-dependent clotting factors II, VII, IX and X .
Tecarfarin sodium has the antithrombotic activity .
D-α-Tocopherylquinone (α-Tocopherylquinone) is a quinone, can be isolated from Phaeodactylum tricornutum. D-α-Tocopherylquinone is a oxidation product of α-Tocopherol (vitamin E). D-α-Tocopherylquinone can act as an anticoagulant and as an antioxidant .
Menaquinone 9 is a vitaminK2 (HY-109569) analog. Menaquinone 9 acts as a prothrombogenic agent and functional electron transfer component in nitrate reductase .
Geranylgeraniol is an orally acitve vitaminK2 sub-type, an intermediate of the mevalonate pathway. Geranylgeraniol targets NF-kB signaling pathway and could alleviate LPS-induced microglial inflammation in animal model .
PPM-18 (NSC 73233), a potent anti-inflammatory agent, inhibits nitric oxide synthase expression. PPM-18 is a potent inhibitor of iNOS expression by blocking the binding of NF-κB to promoter . PPM-18, an analog of VitaminK, induces autophagy and apoptosis in bladder cancer cells through ROS and AMPK signaling pathways .
Activated Protein C (390-404), human is a peptide of the activated protein C (a vitaminK-dependent serine protease), potently inhibits APC anticoagulant activity .
Activated Protein C (390-404), human TFA, a peptide of the activated protein C (a vitaminK-dependent serine protease), potently inhibits APC anticoagulant activity .
H-Phe-Leu-Glu-Glu-Leu-OH is a synthetic pentapeptide, which can be used as the substrate of vitaminK dependent carboxylase, and a glutamyl residue in the generated product is carboxylated .
Osteocalcin (1-49) (human) is a vitaminK-dependent bone specific protein. Osteocalcin (1-49) (human) is chemotactic for several of the cell types frequently found at bone remodeling surfaces .
Osteocalcin, bovine is a vitaminK-dependent bone specific protein. Osteocalcin, bovine is also known as bone gamma-carboxyglutamic acid-containing protein (BGLAP). Osteocalcin, bovine is a small (49-amino-acid) noncollagenous protein hormone .
VitaminK, the blood-clotting vitamin, is important for the function of numerous proteins within the body, such as the coagulation factors, osteocalcin and matrix-Gla protein.
VitaminK4 is a chemically synthesized VitaminK which plays an important role in the normal blood coagulation system. VitaminK4 arrests the cells in S phase and induces apoptosis. VitaminK4 can be used for the research of cancer, such as prostate cancer and osteosarcoma .
NAPQI is the toxic metabolite of Acetaminophen (HY-66005). NAPQI is also an inhibitor of enzymes in the vitaminK cycle. NAPQI is rapidly detoxified by glutathione (GSH), but in situations of GSH deficiency, excess NAPQI reacts with cysteine residues in proteins, causing cell death and toxicity in the liver .
Lapachol, a natural naphthoquinone, is an orally active, potent DHODH inhibitor. Lapachol has immunosuppressive activity on lymphocytes through its direct ability to block DHODH activity and inhibit pyrimidine synthesis. Lapachol is a vitaminK antagonist with antitumor activity and can inhibit DNA and RNA synthesis in neoplastic cells. Lapachol has anti-Leishmania activity .
D-α-Tocopherylquinone (α-Tocopherylquinone) is a quinone, can be isolated from Phaeodactylum tricornutum. D-α-Tocopherylquinone is a oxidation product of α-Tocopherol (vitamin E). D-α-Tocopherylquinone can act as an anticoagulant and as an antioxidant .
Geranylgeraniol is an orally acitve vitaminK2 sub-type, an intermediate of the mevalonate pathway. Geranylgeraniol targets NF-kB signaling pathway and could alleviate LPS-induced microglial inflammation in animal model .
Protein S/PROS1 Proteinas are potent antagonists of BMP4 and inhibit BMP4 by binding to BMP4 and preventing receptor interaction. This change redirects neural stem cells from gliogenesis to neurogenesis, thereby promoting the differentiation of neurons in the brain. Protein S/PROS1 Protein, Human (HEK293, His) is the recombinant human-derived protein S/PROS1 protein, expressed by HEK293 , with C-His labeled tag. The total length of Protein S/PROS1 Protein, Human (HEK293, His) is 676 a.a., with molecular weight of 69-89 kDa.
Factor XIV/PROC protein (or protein C) is an important vitamin K-dependent serine protease that regulates blood clotting. Protein C plays a crucial role in inactivating factors Va and VIIIa and regulating the coagulation cascade in the presence of calcium ions and phospholipids. Coagulation Factor XIV/PROC Protein, Mouse (HEK293, His) is the recombinant mouse-derived Coagulation Factor XIV/PROC protein, expressed by HEK293 , with C-His labeled tag. The total length of Coagulation Factor XIV/PROC Protein, Mouse (HEK293, His) is 442 a.a., with molecular weight of ~63 & 45 kDa, respectively.
Coagulation Factor XIV/PROC is a vital vitamin K-dependent serine protease regulating blood coagulation. Active Protein C inactivates factors Va and VIIIa in the presence of calcium ions and phospholipids, maintaining the intricate balance of coagulation pathways. Its protective effect on endothelial cell barrier function underscores a broader impact on vascular integrity. Coagulation Factor XIV/PROC Protein, Human (HEK293, His) is the recombinant human-derived Coagulation Factor XIV/PROC protein, expressed by HEK293 , with C-His labeled tag. The total length of Coagulation Factor XIV/PROC Protein, Human (HEK293, His) is 443 a.a., with molecular weight of 56-64 & 45 kDa, respectively.
As the catalytic subunit of the VKOR complex, the VKOR1 protein is crucial in vitamin K metabolism and is essential for the reduction of inactive vitamin K 2,3-epoxide to the active form. This process is critical for γ-carboxylation of proteins and is particularly important for blood coagulation and the synthesis of coagulation factors. VKOR1 Protein, Human (HEK293, GFP, His) is the recombinant human-derived VKOR1 protein, expressed by HEK293 , with C-10*His, GFP labeled tag. The total length of VKOR1 Protein, Human (HEK293, GFP, His) is 163 a.a., .
The P371 protein is critical in cellular processes and mediates vitamin K-dependent carboxylation of glutamate residues to form calcium-binding γ-carboxyglutamic acid (Gla) residues. At the same time, it converts the reduced hydroquinone form of vitamin K into vitamin K epoxide. P371 Protein, Human (Sf9, FLAG) is the recombinant human-derived P371 protein, expressed by Sf9 insect cells , with C-Flag labeled tag. The total length of P371 Protein, Human (Sf9, FLAG) is 758 a.a., .
VitaminK1-d7 is the deuterium labeled VitaminK1. VitaminK1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism[1][2].
Menaquinone-7-d7 is the deuterium labeled Menaquinone-7. Menaquinone-7 (VitaminK2-7), belongs to a class of K2-vitamin homologs, is originally discovered as the anti-hemorrhagic factors[1]. Menaquinone-7 (VitaminK2-7) is identified as the most bioactive cofactor for the carboxylation reaction of Gla-proteins [2]. Supplementation with Menaquinone-7 (VitaminK2-7) is a pharmacological option for activating matrix Gla protein and intervening in the progression of calcific aortic valve stenosis (CAVS)[3].
VitaminK1-d4 is the deuterium labeled VitaminK1. VitaminK1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism[1].
Menaquinone-7- 13C6 is the 13C-labeled Menaquinone-7. Menaquinone-7 (VitaminK2-7), belongs to a class of K2-vitamin homologs, is originally discovered as the anti-hemorrhagic factors[1]. Menaquinone-7 (VitaminK2-7) is identified as the most bioactive cofactor for the carboxylation reaction of Gla-proteins [2]. Supplementation with Menaquinone-7 (VitaminK2-7) is a pharmacological option for activating matrix Gla protein and intervening in the progression of calcific aortic valve stenosis (CAVS)[3].
Menaquinone-4-d7 (VitaminK2(MK-4)-d7) is the deuterium labeled Menaquinone-4. Menaquinone-4 is a vitaminK, used as a hemostatic agent, and also a adjunctive therapy for the pain of osteoporosis.
Menaquinone-4- 13C6 is the 13C-labeled Menaquinone-4. Menaquinone-4 is a vitaminK, used as a hemostatic agent, and also a adjunctive therapy for the pain of osteoporosis.